Interleukin 6
Das IL6-Gen kodiert ein Zytokin, welches bei der regulation von Entzündungsprozessen und bei der B-Zell-Reifung beteiligt ist. Genetische Variationen in diesem Gen werden mit der Neigung zu verschiedenen autiommun und autoinflammatorischen Prozessen in Verbindung gebracht. So zum Beispiel der Diabetes Typ 1, das Kaposi-Sarkom, Fehlbildungen der Hirngefäße und die juvenile Arthritis.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Illig T et al. (2004) Significant association of the interleukin-6 gene polymorphisms C-174G and A-598G with type 2 diabetes.
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2. |
Mucida D et al. (2007) Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.
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3. |
Mora JR et al. (2006) Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells.
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4. |
Chen Y et. al. (2006) Interleukin-6 involvement in brain arteriovenous malformations.
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5. |
Sawczenko A et al. (2005) Intestinal inflammation-induced growth retardation acts through IL-6 in rats and depends on the -174 IL-6 G/C polymorphism in children.
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6. |
McLoughlin RM et al. (2005) IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation.
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7. |
Seddon JM et al. (2005) Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers.
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8. |
Liuzzi JP et al. (2005) Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response.
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9. |
Janssen SP et al. (2005) Interleukin-6 causes myocardial failure and skeletal muscle atrophy in rats.
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10. |
Korn T et al. (2007) IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.
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11. |
Pawlikowska L et. al. (2004) Polymorphisms in genes involved in inflammatory and angiogenic pathways and the risk of hemorrhagic presentation of brain arteriovenous malformations.
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12. |
Nemeth E et al. (2004) IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.
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13. |
Möhlig M et al. (2004) Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes.
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14. |
Viereck V et al. (2003) Raloxifene concurrently stimulates osteoprotegerin and inhibits interleukin-6 production by human trabecular osteoblasts.
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15. |
Kiecolt-Glaser JK et al. (2003) Chronic stress and age-related increases in the proinflammatory cytokine IL-6.
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16. |
Boulanger MJ et al. (2003) Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex.
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17. |
Chung HW et al. (2003) Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women.
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18. |
Kristiansen OP et al. (2003) Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females.
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19. |
McFarland-Mancini MM et al. (2010) Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor.
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20. |
Zhang C et al. (2016) CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer.
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21. |
Zhang Q et al. (2015) Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6.
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22. |
Zenker S et al. (2014) A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6.
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23. |
Suthaus J et. al. (2012) HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice.
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24. |
Ellingsgaard H et al. (2011) Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.
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25. |
Harker JA et al. (2011) Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection.
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26. |
Xu Z et al. (2011) miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB.
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27. |
Ghoreschi K et al. (2010) Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling.
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28. |
Powrie F et al. (2003) Immunology. Regulating the regulators.
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29. |
Fairfax BP et al. (2010) An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.
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30. |
Sabio G et al. (2008) A stress signaling pathway in adipose tissue regulates hepatic insulin resistance.
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31. |
Dai J et al. (2008) Adherence to the mediterranean diet is inversely associated with circulating interleukin-6 among middle-aged men: a twin study.
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32. |
Ancrile B et al. (2007) Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.
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33. |
Qi L et al. (2007) Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals.
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34. |
Meng F et al. (2008) Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes.
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35. |
Naugler WE et al. (2007) Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.
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36. |
Lawrence T et al. (2007) Cancer. Sex, cytokines, and cancer.
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37. |
Kawano M et al. (1988) Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas.
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38. |
Cressman DE et al. (1996) Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.
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39. |
Chung U et al. (1996) Association of interleukin-6 and hypoaldosteronism in patients with cancer.
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40. |
Rooney M et. al. (1995) Inflammatory cytokine responses in juvenile chronic arthritis.
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41. |
Weissenbach J et al. (1980) Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies.
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42. |
Sehgal PB et al. (1987) Human beta 2 interferon and B-cell differentiation factor BSF-2 are identical.
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43. |
Hirano T et al. () Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.
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44. |
Ferguson-Smith AC et al. (1988) Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21.
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45. |
Sutherland GR et al. (1988) Interleukin 4 is at 5q31 and interleukin 6 is at 7p15.
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46. |
De Benedetti F et al. (1997) Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.
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47. |
May LT et al. (1988) Synthesis and secretion of multiple forms of beta 2-interferon/B-cell differentiation factor 2/hepatocyte-stimulating factor by human fibroblasts and monocytes.
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48. |
Sehgal PB et al. (1987) Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187.
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49. |
Zilberstein A et al. (1986) Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines.
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50. |
Sehgal PB et al. (1986) Human chromosome 7 carries the beta 2 interferon gene.
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51. |
Bowcock AM et al. (1988) The human "interferon-beta 2/hepatocyte stimulating factor/interleukin-6" gene: DNA polymorphism studies and localization to chromosome 7p21.
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52. |
Tosato G et al. (1988) Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6).
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53. |
Roodman GD et al. (1992) Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone.
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54. |
Santhanam U et al. (1991) Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.
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55. |
Ota N et al. (2001) A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density.
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56. |
Berthier MT et al. (2003) The interleukin 6-174G/C polymorphism is associated with indices of obesity in men.
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57. |
Pasare C et al. (2003) Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells.
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58. |
Ferrari SL et al. (2003) Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women.
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59. |
de Groof F et al. (2002) Acute stress response in children with meningococcal sepsis: important differences in the growth hormone/insulin-like growth factor I axis between nonsurvivors and survivors.
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60. |
Villuendas G et al. (2002) The -597 G>A and -174 G>C polymorphisms in the promoter of the IL-6 gene are associated with hyperandrogenism.
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61. |
Kovalchuk AL et al. (2002) IL-6 transgenic mouse model for extraosseous plasmacytoma.
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62. |
Funatsu H et al. (2002) Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema.
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63. |
Venihaki M et al. (2001) Corticotropin-releasing hormone regulates IL-6 expression during inflammation.
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64. |
Kane M et. al. (2011) Successful transmission of a retrovirus depends on the commensal microbiota.
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65. |
Scheidt-Nave C et al. (2001) Serum interleukin 6 is a major predictor of bone loss in women specific to the first decade past menopause.
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66. |
Chow D et. al. (2001) Structure of an extracellular gp130 cytokine receptor signaling complex.
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67. |
Linker-Israeli M et al. (1999) Association of IL-6 gene alleles with systemic lupus erythematosus (SLE) and with elevated IL-6 expression.
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68. |
Redwine L et al. (2000) Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans.
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69. |
Foster CB et. al. (2000) An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus.
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70. |
Ota N et al. (1999) Linkage of interleukin 6 locus to human osteopenia by sibling pair analysis.
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71. |
Fernández-Real JM et al. (2000) Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects.
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72. |
Fishman D et. al. (1998) The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.
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Update: 14. August 2020