Beta-3-adreneger Rezeptor
Das ADRB3-Gen codiert den beta-3-adrenergen Rezeptor. Mutationen sind mit Adipositas in Zusammenhang gebracht. Die Vererbung folgt einem dominanten Model. Es kann zudem zu synergistischen Reaktionen mit Mutationen in anderen Genen kommen.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Cagliani R et al. (2009) Diverse evolutionary histories for beta-adrenoreceptor genes in humans.
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2. |
Wang X et al. (2004) Effects of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene on insulin sensitivity in small for gestational age neonates.
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3. |
Walston J et al. (2000) Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor.
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4. |
Urhammer SA et al. (2000) Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young Danish subjects.
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5. |
Festa A et al. (1999) Trp64Arg polymorphism of the beta3-adrenergic receptor gene in pregnancy: association with mild gestational diabetes mellitus.
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6. |
Shihara N et al. (1999) The association between Trp64Arg polymorphism of the beta3-adrenergic receptor and autonomic nervous system activity.
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7. |
Hoffstedt J et al. (1999) Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function.
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8. |
García-Rubi E et al. (1998) Trp64Arg variant of the beta3-adrenoceptor and insulin resistance in obese postmenopausal women.
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9. |
Büettner R et al. (1998) The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort.
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10. |
Mitchell BD et al. (1998) A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans.
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11. |
Kim-Motoyama H et al. (1997) A mutation of the beta 3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride.
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12. |
Nagase T et al. (1997) Lack of association between the Trp64 Arg mutation in the beta 3-adrenergic receptor gene and obesity in Japanese men: a longitudinal analysis.
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13. |
Comuzzie AG et al. (1997) A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2.
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14. |
Elbein SC et al. (1996) Role of the beta 3-adrenergic receptor locus in obesity and noninsulin-dependent diabetes among members of Caucasian families with a diabetic sibling pair.
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15. |
Gagnon J et al. (1996) The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and Swedish Obese Subjects cohorts.
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16. |
van Spronsen A et al. (1993) The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes.
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17. |
Clément K et al. (1995) Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.
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18. |
Walston J et al. (1995) Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene.
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19. |
Emorine LJ et al. (1989) Molecular characterization of the human beta 3-adrenergic receptor.
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20. |
Wilkie TM et al. (1993) Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors.
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21. |
Bachman ES et al. (2002) betaAR signaling required for diet-induced thermogenesis and obesity resistance.
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22. |
OMIM.ORG article
Omim 109691
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23. |
NCBI article
NCBI 155
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Update: 14. August 2020